To further investigate the differences between HSPC and AML response to E-selectin blockade, we investigated how loss of E-selectin binding affects cycling of non-malignant HSPC cells (GFP− lineage− Sca-1+ KIT+) compared to AML blasts (GFP+ lineage− CD11b+ KIT+) within the same host. This evidence concerns the gene ITGAM and acute myeloid leukemia.