We then detected the effect of ZNF750 and FOXC2 on Ang-2 and VEGFs, and found ZNF750 knockdown induced up-regulation of Ang-2 and VEGFs in ESCC cells whereas downregulated FOXC2 reversed the phenomenon (Fig. 3f). This evidence concerns the gene FOXC2 and esophageal squamous cell carcinoma.