ZNF750 and esophageal squamous cell carcinoma: Recent studies have profiled ESCC genomic alterations and have identified significantly mutated genes (SMGs) including TP53, ZNF750, NOTCH1, FAT1, NFE2L2, copy number amplifications occurring in SOX2, TERT, FGFR1, MDM1, and common deletions of RB1 etc4–7.