Furthermore, analysis of focal copy number alterations (FCNA < 100 kb) across the 508 ESCC genomes revealed that ZNF750 was present in a significantly deleted focal peak around 17q25.3 (q value = 8.72E–05) and ZNF750 locus was to be deleted in 71 out of 508 tumors (14%, Fig. 1b, c), that was further validated by a real-time quantitative PCR (qRT-PCR) copy number assay (Fig. 1d, e). The gene discussed is ZNF750; the disease is esophageal squamous cell carcinoma.