Consistent patterns were observed in HAEC, another human arterial endothelial cell line (Fig. S3).When transplanted ZNF750 overexpression ESCC cells into subcutaneous, the tumor had a lower microvessel density compared with the control cells (Fig. 2k, l) and decreased expression of CD31 and FLT1, two markers of angiogenesis phenotypes (Fig. 2m, n). The gene discussed is FLT1; the disease is esophageal squamous cell carcinoma.