Given that the DANCR/miR-4707-3p/FOXC2 axis in ESCC, we hypothesize ZNF750 may directly downregulate DANCR expression, strengthened the interaction of miR-4707-3p with FOXC2-3′UTR in a ceRNA manner, leading to degradation of FOXC2 mRNA, thus playing tumor suppressive role in ESCC. The gene discussed is DANCR; the disease is esophageal squamous cell carcinoma.