Consistent with our paired ESCC samples, we found the negatively correlation of ZNF750 mRNA with FOXC2 mRNA in 92 ESCC cases (r = −0.2151, P = 0.0395), 513 cases of head and neck squamous cell carcinoma (r = −0.2211, P < 0.0001), 493 cases of squamous cell carcinoma of lung (r = −0.1327, P = 0.0031), and 300 cases of cervical squamous cell carcinoma (r = −0.1518, P = 0.0085), suggesting a possibility of ZNF750 deregulates FOXC2 expression in human squamous cell carcinoma (Fig. 6c–e).These datas indicate a possibility of ZNF750 deregulates FOXC2 expression in human squamous cell carcinoma. This evidence concerns the gene FOXC2 and head and neck squamous cell carcinoma.