FOXC2 and digestive system cancer: Functionally, knockdown of miR-4707-3p promoted tumor angiogenesis probably by releasing the oncogenic role of FOXC2. FOXC2 has been implicated as an oncogene promoting tumor invasion and metastasis in various of human cancers, for example, it mediated epithelial-mesenchymal transition32, multidrug resistance33, or regulator of vascular development in basal-like breast cancer, non-small cell lung cancer34, colon cancer35.