Based on these results, we concluded that microglial activation and neuroinflammation in amphetamine-sensitized mice may involve elevation of circulating TNF-α rather than a direct effect of amphetamine, and that IL-10 may play a crucial role in inhibiting microglia activation and schizophrenia-relevant behaviors seen in amphetamine-sensitized mice (Fig. 5l). Here, IL10 is linked to schizophrenia.