MAPT and Alzheimer disease: Furthermore, in the P301L transgenic mouse model, Vega et al. (70) showed that Tau phosphorylation at residues Tyr-197 and Tyr-394 correlated with the formation of Tau aggregates and occurred concurrently with serine and threonine phosphorylation (detected by PHF1 antibody at residues Ser-396/Ser-404 and by CP13 at residues Ser-202/Thr-205) known to be implicated in AD pathogenesis (70).