MAPT and early-onset autosomal dominant Alzheimer disease: The misfolding and aggregation of the microtubule (MT)-associated protein Tau have been linked to the pathogenesis of several neurodegenerative disorders (1), including Alzheimer disease (AD) (2), corticobasal degeneration (CBD) (3), progressive supranuclear palsy (3, 4), Pick's disease, argyrophilic grain disease (5), chronic traumatic encephalopathy (CTE) (6), and frontotemporal dementia with parkinsonism linked to chromosome 17 (FTDP-17) (7).