In the brain of individuals affected by AD, aggregated and abnormally hyper-phosphorylated and modified forms of Tau, such as paired helical filaments (PHFs) and straight filaments (SFs), are found as the main component of the neurofibrillary tangles (NFTs), one of the key diagnostic pathological hallmarks of AD, in addition to amyloid plaques (8). Here, MAPT is linked to Alzheimer disease.