Since then, several reports based on antibody recognition or MS have shown that Tau is phosphorylated on residues Tyr-18, Tyr-197, and Tyr-394 (16, 18, 19, 70) in AD and in fetal brain, whereas phosphorylation at positions Tyr-18 (71) and Tyr-394 (18) have been shown to occur under physiological conditions. The gene discussed is MAPT; the disease is Alzheimer disease.