Mutations in a ubiquitin hydrolase, UBP-1 (a close homologue to HAUSP or USP7), were previously identified to modulate susceptibility to ART and chloroquine (CQ) in the rodent-infectious malaria parasite Plasmodium chabaudi after sequential experimental evolution and selection with a series of antimalarial drugs (11). Here, UBP1 is linked to malaria.