Many other epi-drugs (e.g. JQ1, LSD1 inhibitors, and EZH2 inhibitor) in combination with anti-PD1 therapy, have been revealed that they can increase anti-tumour immune response via enhancing T-cell persistence in different cancers, such as lung cancer, TNBC, and lymphoma, etc. [116, 152]. The gene discussed is EZH2; the disease is cancer.