The effect of TrkB expression on TGF-β signaling in various TGF-β-responsive cell lines, including RIE-1 (rat intestinal epithelial), HeLa (cervical cancer), and NMuMG (mouse mammary epithelial) cells, was examined using TGF-β1-responsive reporters (SBE-Luc and 3TP-Luc) to determine the role, if any, of TrkB in TGF-β signaling. Here, TGFB1 is linked to cervical cancer.