OPD among IO-monotherapy patients was associated with a higher tumor PD-L1 expression (mean 65% vs. 41%, p < 0.001) than multifocal progression and was not encountered in any never-smokers in our cohort (p < 0.05), but other clinical characteristics of OPD and diffusely progressive patients were very similar (Table 1). This evidence concerns the gene CD274 and neoplasm.