Apoptotic cell death was observed by treating MDA-MB-231 human breast cancer cells with STAT3-siRNA or inhibiting STAT3, for example, decreased phosphorylation of STAT3 by hydrazinocurcumin was associated with down-regulations of the expressions anti-apoptotic and metastasis-enhancing factors [39,40,41]. This evidence concerns the gene STAT3 and breast cancer.