ADGRV1 and Usher syndrome type 1: For patient P126 (clinically diagnosed with Usher syndrome type I and molecularly diagnosed as compound heterozygote with variants in ADGRV1 gene, Table S1), the correct diagnosed gene was ranked first, but only one of the two diagnosed heterozygous variants was selected as “contributing” to the final Exomiser score (“Not prioritized”, Table 4 and Figure 3).