Zeybel et al. isolated genomic DNA from percutaneous needle biopsies of patients with mild or severe NAFLD and identified significant differences across several CpGs islands within fibrosis-related genes, among which transforming growth factor beta 1 (TGFβ1), Type I Collagen α1 (Col1A1) and Platelet-derived growth factor (PDGFα) [114]. This evidence concerns the gene TGFB1 and metabolic dysfunction-associated steatotic liver disease.