PNPLA3 and metabolic dysfunction-associated steatotic liver disease: In the liver, the presence of genetic variants predisposing to NAFLD development and progression (I148M PNPLA3, E167K TM6SF2, the rs641738 in MBOAT7 gene, the P446L GCKR and others) may alter the effectiveness of beneficial nutrients or accelerate the effects of unhealthy by-products derived from junk food.