MBOAT7 and Hyperinsulinemia: Furthermore, we have recently pointed out that hepatic MBOAT7 down-regulation is a dysfunctional response to inherited or diet-induced hyperinsulinemia and that its reduced expression is enable to induce intracellular fat accumulation in clinical samples, in in vivo models of NAFLD and in genetically edited HepG2 cells (MBOAT7-/-) [87].