PNPLA3 and metabolic dysfunction-associated steatotic liver disease: In an intriguing study, Santoro et al. revealed the presence of an interaction between PNPLA3 rs738409 variant and the dietary ratio of omega-6/omega-3 polyunsaturated fatty acids (PUFA) on hepatic fat content and alanine aminotransferase (ALT), in 127 pediatric NAFLD patients of various ethnicities (58 Caucasians, 30 African-Americans and 39 Hispanics) [53].