For instance, JHDM2A-/- mice, which are deficient of jumonji C (JmjC)-domain-containing histone demethylase 2A (Jhdm2a), develop hallmarks of MetS, such as obesity, hyperglycaemia, hypercholesterolemia, hyperinsulinemia [116]. This evidence concerns the gene KDM3A and Hyperinsulinemia.