The reduced inhibitory effect of SLC-0111 on both tumor cells can be related with the more specific target of its inhibitory action, played mainly on CA-IX isoform, while the stronger inhibitory effect by AA-06-05 can be related to the inhibition of CA-I isozyme, beside the CA-IX isoform (Figure 1), because the CA-II has not been detected in our models. Here, CA2 is linked to neoplasm.