CD8A and neoplasm: Ecto-HSP70 and HSP90 function as DAMPs and control the immunogenicity of dying cells [94] because they can interact with some receptors on APCs’ surface [95], like CD91, LOX1, and CD40 [93], and enable cross-presentation of tumor cells’ antigens to MHC class I molecule and activate CD8+ T-cells [96,97].