Although the impressive immune-modulatory potential of PDT makes it apt to devise effective cancer disease-management plots, high-inflammatory PDT factors can trigger acute inflammation typified by heightened expression of pro-inflammatory cytokines, adhesion molecules’ E-selection and Intercellular Adhesion Molecule 1 (ICAM-1), and quickly amass leukocytes in the treated tumor area [277]. Here, ICAM1 is linked to neoplasm.