Considering an important role of MITF in the regulation of melanoma cell phenotype and response to targeted drugs, including diverse execution of MITF-dependent programs in drug-resistant melanoma cells [122,123,124], further research is necessary to delineate a relationship between activity of MITF and TFE transcription factors and consequences of manipulation of autophagy-lysosomal signaling in melanoma cells. Here, MITF is linked to melanoma.