TP53 and melanoma: As enhanced NGFR/CD271 level is associated with the neural crest-like state of melanoma cells [193], and vemurafenib- or trametinib-resistant cell lines frequently exhibit higher percentages of NGFRhigh cells compared with matched drug-naïve cell lines [124], further research is necessary to delineate whether and how p53 contributes to increased sensitivity of drug-resistant melanoma cells to ferroptosis.