We have analyzed the correlations between four different PET parameters (presence of FL, SUVmax, SUVmean, and volumetric parameters: TMTV and TLG/TLMU) and different clinical variables that reflect myeloma burden (M-component, percentage of plasma cells (PC), beta 2 microglobulin (B2M), free light chains (FLC) levels, creatinine, albumin, and Revised International Staging System (R-ISS). This evidence concerns the gene B2M and plasma cell myeloma.