Recently, TLR2 has been also reported as a mediator between oxidative stress damage in the RPE and the development of complement-mediated retinal pathology in AMD and other retinal neurodegeneration pathologies, so that TLR2 blockade protects photoreceptors and RPE from oxidative stress-induced cell death [86]. The gene discussed is TLR2; the disease is age-related macular degeneration.