In particular, the analysis of a specific protein panel, including Aβ42/Aβ40 ratio, Aβ42, P-tau, T-tau, TIMP-1, NF-L, MMP-9, and MMP-2, was able to reliably distinguish VaD from either AD, LBD, or normal aging [19,20,21,105]. This evidence concerns the gene NEFL and Alzheimer disease.