More specifically, LCL-PLP exerted suppressive actions on the production of MMP-2 (25% reduction of the zymogen form of MMP-2 (p < 0.0001) and 55% reduction of the active form (p < 0.001)) while LCL-DOX doubled the levels of the zymogen as well as the active form of MMP-2 in melanoma in vivo (Figure 5A–C). This evidence concerns the gene MMP2 and melanoma.