Indeed, the repression of TRPV2 abundance in human glioma cell lines was in turn demonstrated to result in the increased expression of cyclin E1, cyclin-dependent kinase 2 (CDK2), transcription factor E2F1 (E2F1), RAF proto-oncogene serine/threonine-protein kinase (RAF1) genes, and the anti-apoptotic gene, Bcl-xL (BCL2L1) [58]. This evidence concerns the gene RAF1 and central nervous system cancer.