PCa cell lines with low AKT/mTOR activity have high levels of eIF4E phosphorylation and a stronger antiproliferative response to MNK inhibition than to rapamycin, while PCa cells with mutated PTEN and constitutively activated AKT/mTOR pathway have lower eIF4E phosphorylation levels that can be robustly induced with mTOR inhibition and counteracted by co-treatment with CGP57380. This evidence concerns the gene PTEN and posterior cortical atrophy.