Microarray analysis of polysome-associated mRNAs of a different PCa cell line using CGP57380 has demonstrate that MNKs are required for translation of mRNAs involved in hypoxia response (specifically HIF1α transcription factor), and cell cycle progression (CDK2, CDK8, CDK9, KAP1, RASSF1, PCNA and PIAS1), which may explain the antiproliferative effect of MNK inhibition in vitro [47] (Figure 7). Here, ATP7A is linked to posterior cortical atrophy.