VNLG-152, a retinamide derivative, and its racemic form VNLG-152R degraded MNK1 and blocked eIF4E phosphorylation producing a decrease in colony formation, migration and invasion, inducing cell death by apoptosis and affecting the cell cycle in MDA-MB-231 and MDA-MB-468, and suppressed the growth of MDA-MB-231 tumor xenografts and in TNBC patient-derived xenograft (PDX) model [84,85,86]. This evidence concerns the gene MKNK1 and neoplasm.