Targeting different proteins than MNKs, both mTORC1/4E-BP1 and MNK1/eIF4E axis are inactivated in NSCLC cell lines as occurs with exportin 1 (XPO1) inhibitor KPT-330, which disrupts the eIF4F translation initiation complex due to a downregulation of mTOR and MNK1 and phosphorylation of mTOR, p70S6K, 4E-BP1, MNK1 and eIF4E [132]. This evidence concerns the gene EIF4EBP1 and non-small cell lung carcinoma.