MKNK1 and neoplasm: Kwegyr-Afful et al. demonstrated that galeterone and its analogs (VNPT55, VNPP414, and VNPP433-3β) synergize with gemcitabine and inhibit PDAC migration, invasion and proliferation of gemcitabine-naïve and resistant PDAC cells through downregulation of MNK1/2 and suppress tumor growth of PDAC xenografts in mice [91] (Figure 8).