EIF4E and sarcoma: In malignant peripheral nerve sheath tumors (MPNSTs), a rare and aggressive sarcoma subtype of neural origin, Lock et al. have demonstrated high MNK/eIF4E activity in primary human tumors and an enhanced antineoplastic effect of MEK inhibitor PD901 combined with MNKs knockdown or inhibition in vitro and in vivo in a mechanism dependent of eIF4E phosphorylation levels [111].