MDM2 and cancer: The increased expression of eIF4E preferentially induces the translation of proteins involved in cancer such as vascular endothelial growth factor (VEGF) and fibroblast growth factor (FGF) that facilitate angiogenesis, Bcl-2 that participates in cell survival, metalloproteases (MMP) involved in invasion and c-Myc, cyclin D1, ornithine decarboxylase (ODC) and the human double minute 2 homolog (HDM2) that regulate cell growth [19,20,33,34,35,36].