Thus, Wen et al. showed that the MNK inhibitor CGP57380 abrogates the eIF4E phosphorylation induced by the mTOR inhibitor RAD001 (everolimus) in NSCLC cells and the combination of both inhibitors exerts synergistic inhibitory effects on cell proliferation, colony formation and inhibits tumor growth of lung cancer xenografts [66]. Here, EIF4E is linked to non-small cell lung carcinoma.