SOCS2 and neoplasm: For example, in hepatocellular carcinoma (HCC) the methyltransferase METTL3 is elevated and contributes to tumor progression by generating higher levels of m6A modification in the suppressor of cytokine signaling 2 (SOCS2) mRNA which results in its increased degradation mediated by the YTH N6-methyladenosine RNA-binding protein 2 (YTHDF2) [112].