Our results are also consistent with the recent evidence that combined angiotensin receptor antagonism and neprilysin (an enzyme deputed to the degradation of natriuretic peptides and other vasoactive substances, including Bk) inhibition by sacubitril/valsartan has a pro-survival effect in reperfused rabbit hearts after myocardial infarction [47]. The gene discussed is MME; the disease is myocardial infarction.