Seizure‐induced impairments in ketogenesis in both brain tissues from PTZ‐kindled rats and Mg2+‐free ACSF‐treated neurons were alleviated by ZAG overexpression, which may be translocated into mitochondria by HSC70 and increase the activity of HADHB in mitochondria, an enzyme known to promote fatty acid β‐oxidation. Here, HADHB is linked to Seizure.