BMI (OR = 1.13; 95 % C.I., 1.05−1.22), HOMA2 (OR = 1.12; 95 % C.I., 1.01−1.26), triglycerides (OR = 2.09; 95 % C.I., 1.35−3.24) and fasting insulin (OR = 1.42; 95 % C.I., 1.01-2.12) were associated with current depression with raised CRP, after adjusting for potential confounders. This evidence concerns the gene CRP and major depressive disorder.