We found trend evidence for an interaction between CRP and BMI (adjusted OR for the interaction term = 1.56; 95 % C.I. 0.98–2.02) and between CRP and triglycerides (adjusted OR for the interaction term = 1.17; 95 % C.I. 0.99–1.38) on risk of current depression. The gene discussed is CRP; the disease is major depressive disorder.