CRP and Insulin resistance: Immuno-metabolic depression has previously been linked with distinct depressive symptomatology such as increased appetite disturbance, weight gain (Lamers et al., 2018), and depressed patients with these symptoms have been found to have higher BMI and CRP levels (Lamers et al., 2013) alongside other cardiometabolic alterations such as insulin resistance (Simmons et al., 2018).