CD274 and neoplasm: IC PD-L1 expression was significantly associated in univariate analyses with OS (Wald P < 0.001), PFS (P < 0.001), ORR (P < 0.001), best tumor size percentage decrease (P = 0.007), and tumor size shrinkage response at a ≥ 20% cutoff (P = 0.006) (Table 2).