Indeed, recent studies in Drosophila have identified genes associated with human neurodevelopmental and psychiatric disorders that disrupt sleep and circadian rhythm, such as the candidate autism-spectrum-disorder gene Cullin-3 (Cul3) [15, 16] and the gene alicorn (alc) linked to the 1q21.1 deletion, another deletion that confers schizophrenia risk [17]. Here, CUL3 is linked to psychiatric disorder.