CCND1 and neoplasm: In the primary tumor region (designated target 1), tumor cells exhibited only 3 copies of MET, 4 to 7 copies of EGFR, 3 to 4 copies of FGFR2, single copies of the genes encoding PD-L1/PD-L2, and significant amplification of CCND1 (Figure 2 and eFigure 5 in the Supplement).