The mammalian NR5A homolog SF-1, is expressed in somatic follicle cells of the ovary in both rodents and humans (Hinshelwood et al., 2003; Tajima et al., 2003), and loss of this SF-1 expression in murine granulosa cells leads to a severe depletion of developing follicles and infertility (Pelusi et al., 2008). The gene discussed is SF1; the disease is Infertility.