APC and hepatocellular carcinoma: Further common tumor suppressing and cell cycle regulation-related genes with promoter hypermethylation are the adenomatous polyposis coli (APC) on chromosome 5q21 and the Ras association domain family protein 1A (RASSF1A) genes on chromosome 3p21.3 with high frequency of promoter hypermethylation in tumor and blood samples of HCC patients (Hu et al. 2010; Huang et al. 2011; Yeo et al. 2005).