DdPCR by Huang et al. and NGS by Liao et al. of TERT mutation (c.1-124C > T) in plasma ctDNA of HCC patients revealed a frequency of 23% and 5% with a high specificity of 85% and 95%, respectively (Huang et al. 2016; Liao et al. 2016). Here, TERT is linked to hepatocellular carcinoma.