However, current screening of proteomic serum markers, such as alpha-fetoprotein (AFP) in HCC or carcinoembryonic antigen (CEA) and carbohydrate antigen (CA) 19.9 in PC have not shown to be effective due to their reduced predictive values (Bolondi et al. 2013; Gamil et al. 2018; Poruk et al. 2013). This evidence concerns the gene AFP and hepatocellular carcinoma.