CTNNB1 and hepatocellular carcinoma: CtDNA analysis on CTNNB1 mutations (c.121A > G, c.122C > T, c.133T > C, c134C > T) resulted in a high specific frequency of about 10% in two small HCC collectives screened by ddPCR and NGS (Huang et al. 2016; Liao et al. 2016).