Recently, plasma cfDNA profiling in 38 patients with advanced PC receiving first-line FOLFIRINOX chemotherapy could demonstrate that 65.8% of patients had at least one common driver gene alteration in KRAS, TP53, SMAD4, or CDKN2A in high concordance with corresponding tumor tissue (Table 2) (Wei et al. 2019). The gene discussed is CDKN2A; the disease is pachyonychia congenita.