Confirming study results of Yi et al., Eissa et al. could show that a two-gene promotor methylation panel of Zinc finger protein basonuclin-1 (BNC1) and A disintegrin and metalloproteinase with thrombospondin motifs 1 (ADAMTS1) increased sensitivity to 97.4% and specificity to 91.6% in plasma cfDNA of early PC stages (Eissa et al. 2019; Yi et al. 2013). This evidence concerns the gene BNC1 and pachyonychia congenita.