Coevaluation of RASSF1A and Long Interspersed Nucleotide Element 1 (LINE-1) as one of the major repetitive DNA sequence of the human genome and most active mediator of retrotransposition revealed LINE-1 hypomethylation in 66.7% and RASSF1A promoter hypermethylation in 73.3% only in HCC serum DNA samples correlating with early recurrence and poor survival after curative resection (Liu et al. 2017). Here, RASSF1 is linked to hepatocellular carcinoma.