The frequency of mutant TP53 in blood and urine ctDNA of HCC studies ranged between 5 and 60% (An et al. 2019; He et al. 2019; Huang et al. 2016; Ikeda et al. 2018a, b; Kaseb et al. 2019; Kimbi et al. 2005; Liao et al. 2016; Lin et al. 2011; Marchio et al. 2018; Riviere et al. 2018; Szymanska et al. 2004; Xiong et al. 2019). The gene discussed is TP53; the disease is hepatocellular carcinoma.