Laryngeal cancer OR is highly increased by the joint effect of genotype and cigarette consumption, with highest effect attributed to the COX2 c.-1329A>G SNP (OR: 18.18, 95% CI: 6.359–51.989, P-value <0.001), followed by the effect of TP53 (P72R) c.215C>G SNP (OR: 10.4; 95% CI: 3.980–27.179, P-value <0.001), and COX2 c.-899G>C (OR: 10.133, 95% CI: 3.598–28.539, P-value <0.001). Here, TP53 is linked to laryngeal carcinoma.