EGFR and neoplasm: In the present study, we determine the frequencies of COX2 c.-899G>C, COX2 c.-1329A>G, EGF c.-382A>G, EGFR c.1562G>A (R521K), and TP53 c.215C>G (P72R) SNPs in a sample of Chilean population of the city of Santiago, and demonstrate that these polymorphisms, affecting genes related to inflammation, and tumor suppression can modify the risk of LSCC.