In the present study, we determine the frequencies of COX2 c.-899G>C, COX2 c.-1329A>G, EGF c.-382A>G, EGFR c.1562G>A (R521K), and TP53 c.215C>G (P72R) SNPs in a sample of Chilean population of the city of Santiago, and demonstrate that these polymorphisms, affecting genes related to inflammation, and tumor suppression can modify the risk of LSCC. Here, TP53 is linked to neoplasm.