A previous study also showed an increased level of C1qb in the senescence-accelerated mouse/prone 8 (SAMP8), a suitable animal model to investigate the fundamental mechanisms of age-related learning and memory deficits, and after treated with Huang-Lian-Jie-Du decoction which has the ability to ameliorate the learning and memory function of central nervous system, C1qb was decreased (Lu et al., 1998), suggesting that overexpression of C1qb may be closely associated with memory impairment. This evidence concerns the gene C1QB and memory impairment.