MAPT and early-onset autosomal dominant Alzheimer disease: Alzheimer’s disease (AD), a common age-related progressive neurodegenerative disease, is characterized by progressive neuronal loss in the hippocampus and cortex, with the accumulation in the brain of extracellular neuritic plaques caused by β-amyloid (Aβ) peptides as well as intracellular neurofibrillary tangles induced by hyperphosphorylated tau proteins, resulting in irreversible memory loss and declined cognitive functioning (Chen et al., 2017; Area-Gomez et al., 2018).