In our study, PLCB2 was negatively correlated with the prognosis of MDS Dnmt3b has been previously reported to suppress Myc‐induced lymphomagenesis in a mouse model, while loss of Dnmt3b accelerates MLL‐AF9 leukaemia progression via enhancing stemness and promoting cell cycle progression,26, 27, 28 which are consistent with our conclusion. Here, PLCB2 is linked to leukemia.