This is not surprising since EPHA2, EPHA8, and EPHB2, are located within the murine Athsq1 atherosclerosis susceptibility locus,25 which is highly homologous to the premature myocardial infarction susceptibility locus in human18 that similarly contains EPHA2, EPHA8, and EPHB2. This evidence concerns the gene EPHB2 and atherosclerosis.