CUL2 and colorectal cancer: (i) Twist1 overexpression downregulates E-cadherin by binding to its promoter (9) (ii) Twist1 overexpression upregulates Vimentin and is mediated by CUL2 (52) (iii) Twist1 overexpression in colorectal cancer cells downregulates BubR1 (Fig. 4A–C) (iv) Twist1 downregulates p53 levels (11) (v) BubR1 levels positively correlate with levels of p53 and γH2AX in response to DNA damage (53) (vi) p53 is required for repair of DNA damage and shows a negative correlation with γH2AX levels (26).