Pettus et al. recently reported an interesting study that applied conventional and advanced analytical approaches to model, predict, and compare hypoglycaemia rates in patients with T2DM receiving Gla-300, or first-generation (insulin glargine 100 U/mL or insulin detemir) or second-generation (insulin degludec) basal insulin analogues, utilising a large, real-world database [17]. Here, INS is linked to type 2 diabetes mellitus.