As shown in the literature, FLG-AS1 may be involved in the pathogenesis of oral cancer [46]; SNAI3-AS1 can promote the growth and metastasis of hepatocellular carcinoma by inducing tumor epithelial to epithelial-mesenchymal transition [47]; LINC02015 is a protective factor for glioblastoma multiforme and is significantly upregulated in metastatic esophageal squamous cell carcinoma [48, 49]. This evidence concerns the gene FLG and lip and oral cavity carcinoma.