CDK1 and colorectal cancer: As for curcumin of 5 μM, it increased the expression of CDK1; it is reported by Chen et al. that a low dose of curcumin (5 μM) inhibits proliferation of colorectal cancer cells by inducing senescence rather than apoptosis [30], and besides, Müllers et al. showed the activity of CDK1/2 after DNA damage promotes senescence [31], so the low dose of curcumin may lead to senescence via CDK1 presumably.