Lin et al. further confirmed this point in animal studies: after exercise, the level of chemerin/CMKLR1 in the serum, liver, and gastrocnemius of obese and type 2 diabetic mice decreased significantly, which could be reversed by PPARγ antagonist GW9662 and further strengthened by PPARγ agonist pioglitazones [116]. The gene discussed is RARRES2; the disease is type 2 diabetes mellitus.