Additionally, the migration of prostate cancer cells to the bone tissue enhances the expression of RANK, RANKL, and OPG; activates the RANK/RANKL signal pathway in an autocrine or paracrine manner; and activates the NF-κB pathway, which is downstream of the RANK/RAsNKL pathway. The gene discussed is TNFRSF11B; the disease is Familial prostate cancer.