Other candidate genes convoluted in the JAK-STAT pathway associated with hematological malignancies are STAT6 and RUNX1. TUBA1C, located at chromosome 12 is a member of tubulin family of microtubules ubiquitously expressed in the esophagus, bone marrow, appendix, brain, colon, bladder and placenta   41 . This evidence concerns the gene STAT6 and hematologic disorder.