Another study has been indicated that GSTP1, CCND2, RASSF1A, SPINT2, APC, RUNX3, and CFTR are aberrantly methylated in HCC 16. There are similar reports about p16 (INK4a), p15 (INK4b) 17, GSTP1 in HCC Hep3B, HepG2 18, and GSTP1 in HCC Hep3B19. This evidence concerns the gene APC and hepatocellular carcinoma.