SLC5A5 and thyroid gland undifferentiated (anaplastic) carcinoma: Furthermore, in some specific cancers such as anaplastic thyroid cancer that are resistant to radioactive iodine therapy due to loss of NIS expression, the use of MV-NIS in combination with radioactive iodine can be employed as an effective alternative approach, allowing the elimination of this resistance and destruction of cancer cells both in vitro and in vivo [73].