Based on these data and the previous reports about the candidate miRNAs’ function and the number of predicted target sites, we chose eight cancer-related or tumour-suppressing miRNAs for further investigation, including miR-7-5p,30 miR-18a,31 miR-30b-3p,32 miR-122,33 miR-149,34 miR-494,35 miR-63636 and miR-936.37 MiR-30b-3p decreased luciferase activity in pmirGLO-HNF1A-AS1 (Fig. 4c, d), but not in MUT-1 (Fig. 4e, f), indicating that the miRNA can directly bind to HNF1A-AS1 through their respective miRNA- binding sites (Supplementary Fig. 1l). Here, HNF1A is linked to cancer.