PIK3CD and cancer: Recent studies showed that the activation of the PI3K/AKT pathway in tumour cells increases the secretion of VEGF-A25 and VEGF-C.26 VEGF-A exerts a pro-angiogenic role in human cancer,27 and VECF-C is a well-known regulator of the lymphangiogenesis.28 Therefore, an ELISA assay was performed to demonstrate the effect of HNF1A-AS1 on VEGF-A and VEGF-C secretion.