It is known that angiogenesis promotes the initial development of primary malignant tumours, and is closely connected with infiltration and metastasis of cancer cells,39 and that new lymphatic vessels formed through lymphangiogenesis are responsible for cancer metastasis.40 Thus, we concluded that HNF1A-AS1 enhanced GC metastasis maybe due to its effect on angiogenesis and lymphangiogenesis. The gene discussed is HNF1A; the disease is cancer.