CD8A and non-small cell lung carcinoma: In addition, it is well-known that the infiltration of immune cells, especially the intratumoural CD8-positive T cells, is an important predictor of the effective response to IC blockade therapy.3,4 Accordingly, it is considered that 11βHSD1 is a new indicator for poor response to IC blockade therapy, and the additional use of 11βHSD1 inhibitor may increase the efficacy of IC blockade therapy in NSCLC.