This includes malignant melanoma, oesophagus adenocarcinoma, ovarian cancer and so on.31–33 Several reports describe the effect of IL-6 on intratumoural T-cell induction.34,35 However, IL-6 is a multifunctional cytokine with both immunosuppressive and immune-promotive effects.36,37 Further investigation is required regarding the clarification of its actions in this area. The gene discussed is IL6; the disease is melanoma.