In addition since TGFβ, as mentioned before, has pleiotropic effects, it is not only related with bone but its activity is also observed in ovarian, pancreatic, colon cancers and in squamous cell carcinoma and is reported that the over activity causes Camurati-Engelmann disease of bone, which occurs because of a missense mutation in the latency associated peptide that causes a constitutively active TGFβ [94]. This evidence concerns the gene TGFB1 and malignant colon neoplasm.