The largest subset in the TGFβ superfamily is represented by BMPs which are actively effective in ectopic and heterotropic bone formation as well as morphogenesis, bone remodeling, fracture repair, proliferation, differentiation, migration, osteoclastogenesis, osteogenesis, stem cell commitment, carcinogenesis, tumor invasion and metastasis, apoptosis, extracellular matrix remodeling, collagen synthesis, immune functions, through direct or indirect mechanisms and can act in endocrine, paracrine and autocrine manner to establish cell and tissue organization [1,8,20,28,31,32,33,39,42–46]. The gene discussed is CLN5; the disease is neoplasm.