BMP2 and radiculitis: The use of BMP-2 in spine for anterior lumbar spinal fusion has approved by FDA (US Food and Drug Administration), yet the excess amount of BMP, leakage or uncontrolled burst release can cause inflammation, edema, nerve root compression and seroma formation, radiculitis, ectopic bone formation, immune response, osteolysis, cervical and soft tissue edema, osteoclast mediated bone resorption, wound complications, urogenital disorders, inappropriate adipogenesis and heterotrophic bone formation [1,2,11,19,20].