A highly potent derivative of S63845 called S64315/MIK655 shows substantial in vivo activity against MM, AML and MYC-driven lymphomas and is also being tested in clinical trials for these malignancies as a monotherapy (NCT02992483, NCT02979366) and in combination with Venetoclax (NCT03672695) [165]. This evidence concerns the gene MYC and lymphoma.