PHTF2 and gastric cancer: To evaluate the role of PHTF2 on the tumorigenic ability of gastric cancer cells, PHTF2 was stably silenced in GCIY and NUGC3 cell lines, and cell viability was observed to be significantly downregulated caused by PHTF2 knockdown, but restoration of PHTF2 expression was found to rescue cell viability to some extent (Figure 4A).