SLE susceptibility is associated with both TNFAIP3 rs2230926 (OR = 1.9, 95% CI 1.6–2.4, P = 8.8 × 10−11) and UBE2L3 rs131654 (OR = 1.2, 95% CI 1.1–1.4, P = 1.1 × 10−4) SNPs, as their P values are much lower than a significance threshold of Bonferroni correction for 2-SNP testing, α = 0.05/2 = 0.025. The gene discussed is UBE2L3; the disease is systemic lupus erythematosus.