Interestingly, the fasting glucose levels were significantly lower in the HE group compared with the HFD group (at 30 and 60 min, 20.1 ± 0.500 mmol/L vs 27.3 ± 0.656 mmol/L, 16.5 ± 0.751 mmol/L vs 23.3 ± 0.500 mmol/L, p < 0.001), and insulin levels in the HE group were significantly lower compared with those observed in the HFD group (at the end of ITT, 11.2 ± 0.31 mmol/L vs 14.7 ± 0.60 mmol/L, p < 0.01). The gene discussed is INS; the disease is hereditary elliptocytosis.