After adjusting for onset age of diabetes, SBP, DBP, TC and CRP, the results illustrated that age and HSP27 were still independently associated with carotid IMT in type 2 diabetes, with adjusted odds ratios of 1.061 (P = 0.028) and 1.085 (P = 0.022), respectively (Table 3). This evidence concerns the gene CRP and type 2 diabetes mellitus.